Abstract
We report on a novel dibenzothiophene-based two-photon fluorescent probe for
selective nuclear bioimaging, which contains bilaterally symmetrical pyridine rings
connected by a central conjugated-bridge dibenzothiophene. This probe possesses a large
two-photon absorption cross-section of 471 GM, yields a 25-fold enhancement of the
fluorescence titration, and a stronger photostability for nuclei labeling than existing
probes. The real-time observation period is a minimum of 1800 s under a femtosecond
laser excitation, which is significantly longer than that of
4′,6-diamidino-2-phenylindole. The above results confirm that this novel
molecule is a suitable two-photon fluorescent probe for application to nuclear
bioimaging in cells.
© 2016 Chinese Laser Press
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