Abstract
The method uses linear systems techniques to model the tissue concentration of a near-infrared chromophore following an abrupt change in the arterial concentration. A robust deconvolution algorithm was developed to derive the impulse residue function (IRF) of the cerebral circulation from the arterial and tissue concentration vs time data measured with near-infrared spectroscopy. The height of the derived IRF is cerebral blood flow (CBF) in absolute physiological units. Experimental studies in human volunteers shows that the precision of CBF measurements with the method is about 12%. Cerebrovascular reactivity towards arterial carbon dioxide tension was also demonstrated in piglets.
© 2000 Optical Society of America
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