Abstract
Wave-based optical coherence elastography (OCE) is a rapidly emerging technique for elasticity assessment of tissues having high displacement sensitivity and simple implementation. However, most current noncontact wave excitation techniques are unable to target a specific tissue site in 3D and rely on transversal scanning of the imaging beam. Here, we demonstrate that dye-loaded perfluorocarbon nanoparticles (nanobombs) excited by a pulsed laser can produce localized axially propagating longitudinal shear waves while adhering to the laser safety limit. A phase-correction method was developed and implemented to perform sensitive nanobomb elastography using a Fourier domain mode-locking laser. The nanobomb activation was also monitored by detecting photoacoustic signals. The highly localized elastic waves detected by the nanobomb OCE suggest the possibility of high-resolution 3D elastographic imaging.
© 2019 Optical Society of America
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Chih-Hao Liu, Dmitry Nevozhay, Hongqiu Zhang, Susobhan Das, Alexander Schill, Manmohan Singh, Salavat Aglyamov, Konstantin V. Sokolov, and Kirill V. Larin, "Longitudinal elastic wave imaging using nanobomb optical coherence elastography: erratum," Opt. Lett. 45, 3296-3296 (2020)https://opg.optica.org/ol/abstract.cfm?uri=ol-45-12-3296
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