Abstract

Coded aperture spectroscopy allows for sources of large étendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve <i>r</i>² > 0.98. Leave-one-out cross-validation demonstrates prediction errors of, <15% at the common legal limit for intoxication (17.4 mmol/L = 0.08% by vol) and the best blind cross-validation achieves <12% error at this concentration.

Performance comparison of aperture codes for multimodal, multiplex spectroscopy

Ashwin A. Wagadarikar, Michael E. Gehm, and David J. Brady
Appl. Opt. 46(22) 4932-4942 (2007)

Static two-dimensional aperture coding for multimodal, multiplex spectroscopy

Michael E. Gehm, Scott T. McCain, Nikos P. Pitsianis, David J. Brady, Prasant Potuluri, and Michael E. Sullivan
Appl. Opt. 45(13) 2965-2974 (2006)

Snapshot depth sensitive Raman spectroscopy in layered tissues

Wei Liu, Yi Hong Ong, Xiao Jun Yu, Jian Ju, Clint Michael Perlaki, Lin Bo Liu, and Quan Liu
Opt. Express 24(25) 28312-28325 (2016)

Development of a multi-needle fiberoptic Raman spectroscopy technique for simultaneous multi-site deep tissue Raman measurements in the brain

Bocheng Qiu, Chi Shu, and Zhiwei Huang
Opt. Lett. 48(16) 4396-4399 (2023)

Coded aperture spectroscopy with denoising through sparsity

Alex Mrozack, Daniel L. Marks, and David J. Brady
Opt. Express 20(3) 2297-2309 (2012)