Exploration of the retinal nerve fiber layer thickness by measurement of the linear dichroism

Olivier Karim Naoun; Valérie Louis Dorr; Paul Allé; Jean-Christophe Sablon; Anne-Marie Benoit

doi:10.1364/AO.44.007074

Applied Optics
Vol. 44,
Issue 33,
pp. 7074-7082
(2005)
•https://doi.org/10.1364/AO.44.007074

Exploration of the retinal nerve fiber layer thickness by measurement of the linear dichroism

Olivier Karim Naoun, Valérie Louis Dorr, Paul Allé, Jean-Christophe Sablon, and Anne-Marie Benoit

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Olivier Karim Naoun, Valérie Louis Dorr, Paul Allé, Jean-Christophe Sablon, and Anne-Marie Benoit, "Exploration of the retinal nerve fiber layer thickness by measurement of the linear dichroism," Appl. Opt. 44, 7074-7082 (2005)

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Abstract

An electro-optic device mounted on a slit lamp to assess the degree of polarization of a light beam that has double passed through the retina about the optic-nerve head in the living human eye is described. The asymmetric structure of the retinal nerve’s fiber layer possesses a linear-form dichroism and will partially polarize an unpolarized light beam that is scattered at the fundus of the eye and has double passed the ocular media (cornea, lens, retina). This partial polarization is a function of the retinal nerve’s fiber layer thickness, and its measurement may be used for exploring glaucoma and other retinal neuropathies. Experimental conditions allow us to neglect corneal dichroism. The first clinical measurements show a different degree of polarization between normal and glaucomatous eyes and a good correlation with the results obtained by optical coherence tomography.

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Eye Number	Age of Patient (Years)	Point	ADR 100*P	OCT Location	OCT l_R (µm)	Δκ (µm⁻¹)
1	58	1	32	Inf	172	9.3 × 10⁻⁴
		2	31	Sup	155	1.0 × 10⁻³
		3	23	Nas	97	1.2 × 10⁻³
		4	18	Temp	91	9.9 × 10⁻⁴
2	66	1	24	Inf	194	6.2 × 10⁻⁴
		2	23	Sup	126	9.1 × 10⁻⁴
		3	20	Nas	103	9.7 × 10⁻⁴
		4	16	Temp	77	1.0 × 10⁻³
3	72	1	32	Inf	127	1.2 × 10⁻³
		2	29	Sup	126	1.2 × 10⁻³
		3	19	Nas	106	9.0 × 10⁻⁴
		4	9	Temp	57	7.9 × 10⁻⁴
4	63	1	27	Inf	127	1.1 × 10⁻³
		2	26	Sup	133	1.0 × 10⁻³
		3	20	Nas	107	9.6 × 10⁻⁴
		4	14	Temp	49	1.4 × 10⁻³
5	78	1	29	Inf	121	1.2 × 10⁻³
		2	23	Sup	125	9.2 × 10⁻⁴
		3	16	Nas	72	1.1 × 10⁻³
		4	12	Temp	65	9.2 × 10⁻⁴

Eye Number	Age of Patient (Year)	Abnormality of Visual Field	Point	ADR 100*P	OCT Location	OCT l_R (µm)	Δκ (µm⁻¹)
6	63	Superior scotoma	1	10	Inf	96	5.2 × 10⁻⁴
			2	15	Sup	157	4.8 × 10⁻⁴
			3	4	Nas	66	3.0 × 10⁻⁴
			4	7	Temp	78	4.5 × 10⁻⁴
7	54	Advanced glaucoma	1	8	Inf	51	7.8 × 10⁻⁴
			2	5	Sup	36	6.9 × 10⁻⁴
			3	4	Nas	44	4.5 × 10⁻⁴
			4	6	Temp	36	8.3 × 10⁻⁴
8	38	Advanced glaucoma, posttrauma	1	6	Inf	60	5.0 × 10⁻⁴
			2	6	Sup	52	5.8 × 10⁻⁴
			3	8	Nas	82	4.9 × 10⁻⁴
			4	5	Temp	33	7.6 × 10⁻⁴
9	85	Advanced glaucoma, atrophy	1	6	Inf	30	1.0 × 10⁻³
			2	5	Sup	56	4.5 × 10⁻⁴
			3	5	Nas	36	6.9 × 10⁻⁴
			4	3	Temp	48	3.1 × 10⁻⁴
10	56	Diffuse loss	1	5	Inf	77	3.2 × 10⁻⁴
			2	6	Sup	69	4.3 × 10⁻⁴
			3	2	Nas	42	2.4 × 10⁻⁴
			4	2	Temp	47	2.1 × 10⁻⁴

Eye Number	Age of Patient (Years)	Point	ADR 100*P	OCT Location	OCT l_R (µm)	Δκ (µm⁻¹)
1	58	1	32	Inf	172	9.3 × 10⁻⁴
		2	31	Sup	155	1.0 × 10⁻³
		3	23	Nas	97	1.2 × 10⁻³
		4	18	Temp	91	9.9 × 10⁻⁴
2	66	1	24	Inf	194	6.2 × 10⁻⁴
		2	23	Sup	126	9.1 × 10⁻⁴
		3	20	Nas	103	9.7 × 10⁻⁴
		4	16	Temp	77	1.0 × 10⁻³
3	72	1	32	Inf	127	1.2 × 10⁻³
		2	29	Sup	126	1.2 × 10⁻³
		3	19	Nas	106	9.0 × 10⁻⁴
		4	9	Temp	57	7.9 × 10⁻⁴
4	63	1	27	Inf	127	1.1 × 10⁻³
		2	26	Sup	133	1.0 × 10⁻³
		3	20	Nas	107	9.6 × 10⁻⁴
		4	14	Temp	49	1.4 × 10⁻³
5	78	1	29	Inf	121	1.2 × 10⁻³
		2	23	Sup	125	9.2 × 10⁻⁴
		3	16	Nas	72	1.1 × 10⁻³
		4	12	Temp	65	9.2 × 10⁻⁴

Eye Number	Age of Patient (Year)	Abnormality of Visual Field	Point	ADR 100*P	OCT Location	OCT l_R (µm)	Δκ (µm⁻¹)
6	63	Superior scotoma	1	10	Inf	96	5.2 × 10⁻⁴
			2	15	Sup	157	4.8 × 10⁻⁴
			3	4	Nas	66	3.0 × 10⁻⁴
			4	7	Temp	78	4.5 × 10⁻⁴
7	54	Advanced glaucoma	1	8	Inf	51	7.8 × 10⁻⁴
			2	5	Sup	36	6.9 × 10⁻⁴
			3	4	Nas	44	4.5 × 10⁻⁴
			4	6	Temp	36	8.3 × 10⁻⁴
8	38	Advanced glaucoma, posttrauma	1	6	Inf	60	5.0 × 10⁻⁴
			2	6	Sup	52	5.8 × 10⁻⁴
			3	8	Nas	82	4.9 × 10⁻⁴
			4	5	Temp	33	7.6 × 10⁻⁴
9	85	Advanced glaucoma, atrophy	1	6	Inf	30	1.0 × 10⁻³
			2	5	Sup	56	4.5 × 10⁻⁴
			3	5	Nas	36	6.9 × 10⁻⁴
			4	3	Temp	48	3.1 × 10⁻⁴
10	56	Diffuse loss	1	5	Inf	77	3.2 × 10⁻⁴
			2	6	Sup	69	4.3 × 10⁻⁴
			3	2	Nas	42	2.4 × 10⁻⁴
			4	2	Temp	47	2.1 × 10⁻⁴

Abstract

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Tables (2)

Equations (22)

Applied Optics