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Performance of THz fiber-scanning near-field microscopy to diagnose breast tumors

Hua Chen, Wen-Jeng Lee, Hsin-Yi Huang, Chui-Min Chiu, Yuan-Fu Tsai, Tzu-Fang Tseng, Jen-Tang Lu, Wei-Ling Lai, and Chi-Kuang Sun

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Abstract

Based on tissues from 20 female patients (mean age: 53 years; rang: 36-72 years), we examine the performance of a room-temperature-operated terahertz (THz) fiber-scanning near-field microscopy to diagnose slices of breast tissues. The specimens were frozen sliced and then measured in a thawed state without dehydration. We performed the imaging at 320GHz. Our study indicates that images acquired in the THz transmission-illumination mode can all clearly distinguish breast tumor tissues from normal tissues without H&E staining. Due to its capability to perform quantitative analysis and to allow follow-up staining and traditional pathohistological analysis, our study indicates great potential of the THz fiber-scanning near-field microscopy for future automation, which is critical for fast and complete pre-screening on breast tumor pathological examinations and for assisting quick definition of the tumor margins during the surgical procedure such as breast-conserving surgery.

©2011 Optical Society of America

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Figures (3)
Fig. 1
Fig. 1 Schematic of the THz fiber-scanning near-field microscopy.

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Fig. 2
Fig. 2 The THz near-field microscopic images of Case 1-Case 4 and the corresponding pathologic photomicrograph of H&E stained sections. The areas of breast tumor in the pathologic photomicrographs were marked by a black solid boundary.

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Fig. 3
Fig. 3 The THz near-field microscopic images of Case 5 - Case 20 and the corresponding pathologic photomicrograph of H&E stained sections. The areas of breast tumor in the pathologic photomicrographs were marked by a black solid boundary.

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