Abstract
Barrett’s Esophagus (BE) is a common pre-cursor condition to esophageal adenocarcinoma (EAC); the monitoring of which can facilitate the detection of dysplastic tissue, and the treatment of subsequent early stage EAC. Early detection of EAC improves survival rates significantly. Optical Coherence Tomography is a low coherence interferometric technique which produces depth scans of tissues. OCT provides morphological information, but lacks in specificity, and so can be combined with Near Infrared Fluorescence imaging, to also retrieve molecular information. Fluorescently labelled monoclonal antibodies can be administered in order to label specific tissues, which can then be imaged using this OCT-NIRF technique. Fluorescently labelled bevacizumab combined with OCT-NIRF imaging will highlight inflamed, dysplastic and pre-/ cancerous tissues, such as BE tissue. Here, a silicon elastomer phantoms are used to quantify the fluorescence intensity signal detected from a dilution of fluorescent bevacizumab: the fluorescent signal intensity is correlated as a function of fluorophore depth and concentration, and ′value of the phantom material.
© 2023 SPIE
PDF ArticleMore Like This
Yu Chen
BMB4 Bio-Optics: Design and Application (BODA) 2011
Loretta Scolaro, Dirk Lorenser, Wendy-Julie Madore, Anne Kramer, George C. Yeoh, Nicolas Godbout, David D. Sampson, Caroline Boudoux, and Robert A. McLaughlin
BS2B.7 Biomedical Optics (BIOMED) 2014
A. Kalyanov, M. Ackermann, E. Russomanno, M. Wolf, and J. Jiang
1262812 European Conference on Biomedical Optics (ECBO) 2023